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Useful information :: HIV/AIDS
HIV/AIDS


HIV

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HIV virusНІV-инфекция/СПИН 

Причинител - човешки имунодефицитен вирус - тип 1 и 2 (НІV-1 и НІV-2). НІV-1 причинява повечето от случаите в западното полукълбо, Европа и Централна, Южна и Източна Африка, а НІV-2 - в западна Африка.  Счита се, че по-малката вирулентност на НІV-2 е една от причините за по-слабото му разпространение.

Благодарение на съдържащия се в НІV ензим обратна транскриптаза, неговата РНК се превръща в провирусна ДНК, която се прикрепва към ДНК на човешките клетки. Провирусите се делят заедно с гените на клетката при всяко нейно делене и така цялото поколение на инфектираната клетка съдържа провирусната ДНК. Същевременно с това могат да се образуват вирусни частици, които атакуват други клетки.

НІV атакува основно т.нар. Т-лимфоцитни клетки, които имат важна роля в поддържането на имунитета срещу инфекции и тяхното намаляване обуславя в най-значителна степен развитието на симптомите на СПИН. СПИН означава Синдром на Придобита Имунна Недостатъчност и се характеризира с развитие на инфекции и неоплазми, с които увредената имунна система не може да се справи, а също и с увреждания на нервната система поради директно атакуване на клетките й от НІV.

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Useful information :: HIV/AIDS