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Prof. Radka ArgirovaПроф. д.м.н. Радка Аргирова, вирусолог, Аджъбадем Сити Клиник ДКЦ и Токуда Болница, София

Преди да  опишем особеностите в специфичната диагностика на HIV-инфекцията,  ще дефинираме някои основни понятия от областта HIV/СПИН. HIV-инфекцията се определя като периодът от момента на заразяване с HIV до смъртта при естествен ход на инфекцията. СПИН е последната фаза на HIV инфекцията, като съществуват ясно определени критерии – клинични и лабораторни -  за поставяне на диагнозата  СПИН. Симптомите на остра/ хронична HIV инфекция при възрастни и деца са описани в Приложение 1 към чл.10,т.1 на Наредба N 47 на МЗ, обнародвана в ДВ, бр.103/29.12.2009 г.  В Приложение 2 към чл.10,т.2 на същата Наредба са описани индикаторните заболявания за СПИН.
Прозоречен период е времето между заразяването с HIV и появата в кръвта на биохимично измерими маркери на инфекцията (най-често  антитела, но като маркери могат да бъдат използвани и вирусспецифични антигени, както и вирусна РНК). Сероконверсия е моментът, в който се откриват биохимично измеримите маркери (най-често антитела към HIV, които най-вероятно се формират по-рано, отколкото се откриват). Практически, прозоречният период е времето между заразяването и откриването на антивирусните антитела. HIV антителата се откриват най-рано 2 седмици след заразяването, в 60-65% от случаите се откриват след 4 седмици, в 80% - след 6 седмици, в 90% - след 8 седмици и в 95-98% - след 12 седмици. При съвременните тестове от 4-то поколение освен анти-р24 антителата, се открива и р24 антигена – около 4-5 дни преди появата на антителата. Най-ранно определимият лабораторен маркер е HIV РНК, която пък се открива около 6-7 дни преди р24 антигена. Следователно, няма никакъв смисъл да се търсят специфични маркери на HIV преди началото на втората седмица след заразяването.



Latest news

Covid-19 pandemic – analyzed and explained
Sofia, January 7, 2021
Online meeting with Prof. Radka Argirova, MD, leading virologist with prominent scientific and practical experience was held on January 7th, 2021. The meeting provoked interest and attracted attention of more than 80 people from all regions of the country – among them were representatives of Learning Action Partnership (LAP), BFPA staff and Management bard, NGOs, institutions, medical doctors and health mediators. The topic of the event was ‘ SARS-CoV-2 – About the Virus, Specific Diagnostics and Vaccines’ . During the more than two hours and a half lasted forum was presented a lecture including information about arising epidemics and pandemics, mechanisms of occurrence and evolution of viruses; main generally accepted facts, diagnosis and development of Covid 19. Review of the types of tests for Covid 19 was made, qualities of antigen test and types of PCR tests were discussed, as special attention was drawn to cases with false negative results, asymptomatic patients, and symptomatic patients with negative results. Special attention was also given to the different vaccines elaborated to combat the virus. Participants took the opportunity to ask additional questions after the lecture. You can listren to them in Bulgarian here
Outwitting the pandemic - in search of digital applications for health education and information

Sofia, Montana, Yambol, December 2020

Despite the restrictions imposed by the measures against Covid 19, in recent months the planned activities in the second year of the project "My body, my rights", supported by the socially responsible business program "MSD for mothers", continue in three locations - Sofia, Montana and Yambol. The coordinators of the project by places - Fakulteta district in Sofia - Valentin Blagoev, Kosharnik quarter and Ogosta quarter in Montana - Petar Tsvetanov and the whole Tundzha municipality in Yambol (the villages of Veselinovo, Kukorevo, Tenevo, Zavoy) - Kina Assenova, hold meetings of self-help groups - though in  more limited numbers due to precautionary measures, conduct training events for young people - outdoors, through specialized stands for distribution of printed materials for the project itself and for the SRH in general, and most importantly - support marginalized members of communities with hygiene materials, essential goods and medicines and specialized information for prevention from Covid, along with the usual topics - prevention of unwanted pregnancy, prevention of STIs, maternal and child health and many others, through selfless and exhausting walking from the neck of door due to the impossibility to organize large information sessions.

Break the Silence: Sexual Exploitation and Sexual Violence of Children Could Happen Everywhere

Sofia, November 18, 2020

Break the Silence: November 18 is the European Day on protection of children against sexual exploitation and sexual violence.
The first thing that comes to mind when we hear ‘sexual exploitation’ is usually connected with red lanterns, streets or roads with women (and men) sex workers, trafficking of human beings. Sexual exploitation of children could have also other faces – sex services in exchange of expensive things such as smart phone or modern accessory or at the cost of a lunch, sweets or instead of rent for parents’ accommodation. It can happen via internet and to affect minors before they become teenagers. That’s why it is needed to break the silence and to ask for zero tolerance concerning this ugly phenomenon. Statistics show that one of five children becomes victim of violence, including sexual. As parents we can prevent this: we can teach them for instance on the Rule of the Bathing Suit. It says that no one has the right to touch their body, especially where the body is covered by a swimming bathing suit. Medical examinations and manipulations as well don’t have to be allowed without their informed consent. The rule helps children to understand that their bodies are their own, that there is good and bad touching, as well es personal borders and social ethnic norms.